A novel wax matrix enteric coated tablet compare with polymer matrix enteric coated tablet of metoclopramide. The wax matrix tablet give more sustain effect as compare with polymer. The wax matrix tablet is prepared by melt granulation technique. Bioavailability is less and the half life is 2 hr. The dose of metoclopramide is 10 mg 4 times a day so due to this frequency of the drug taken is higher, through this approaches sustain delivery of the drug can be achieved. So, the patient compliance is increases by the reducing dose. A novel wax is use as matrixing agent like (Ozokerit and Candelilla wax) and compared with HPMC K 100 and EC and 8 batch formulated. Among them F2 and F4 batch containing Ozokerit and Candelilla wax shows maximum delay release.
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